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OCR: in (ADF The main physiological role of vasopre the is the reduction of free-water clearance b asopressin kidney to produce concentrated urine. V ter acts on the distal nephron to increase w lute-free permeability of the tubular cell so that s at from the water may pass along the osmotic gradie titial lumen of the nephron to the renal inter medulla. See later: Other Effects of Vasopressin Regulation of Vasopressin Secretion on and · Osmoregulation of Vasopressin Secret Thirst Issin . Plasma Osmolality and Plasma Vasop n Baroregulation of Vasopressin Secreti · Renal Action of Vasopressin . Analogues of Vasopressin